9/25/2023 0 Comments Synergy gas wilmingtonThe outbreaks of this communicable disease inflict a huge burden on populations, health systems and economies in most tropical countries. Dengue virus is the most serious pathogenic hemorrhagic fever infecting humans, with an estimated 50–100 million cases each year and over 2.5 billion people at risk worldwide. (Diptera: Culicidae), is a dominant vector capable of transmitting dengue fever and other infectious viral diseases such as yellow fever, chikungunya and Zika, which pose a great and continued threat to mankind. aegypti presents a promising role of EOs as a synergist for improving mosquitocidal efficacy, particularly in situations where conventional compounds are ineffective or inappropriate. The synergy of enhanced adulticidal toxicity recorded from EO-permethrin combinations against both strains of Ae. galanga also reduced the LD 50 values of permethrin against PMD-R drastically from 3.70 to 0.42 and 0.003 ng/mg female, respectively, with SR values of 8.33, respectively. galanga oils decreased the LD 50 values of permethrin against MCM-S dramatically from 0.44 to 0.07 and 0.11 ng/mg female, respectively, with synergism ratio (SR) values of 6.28 and 4.00, respectively. Significant synergistic effects with permethrin against both the strains of Ae. Nevertheless, combination-based bioassays discovered the accomplished synergism of EOs together with permethrin. aegypti of these EOs was close to that of piperonyl butoxide (PBO, LD 50 values = 6.30 and 4.79 μg/mg female, respectively) but less pronounced than that of permethrin (LD 50 values = 0.44 and 3.70 ng/mg female, respectively). The adulticidal efficacy against MCM-S and PMD-R Ae. aegypti, both MCM-S and PMD-R strains, with LD 50 values of 10.05 and 9.57 μg/mg female, 7.97 and 7.94 μg/mg female, and 3.30 and 3.22 μg/mg female, respectively. Cyperene (14.04%), β-bisabolene (18.27%) and cinnamaldehyde (64.66%) were the main constituents of C. verum, representing 80.22%, 86.75% and 97.24%, respectively, of all compositions. ResultsĬhemical characterization by the GC-MS analytical technique demonstrated that 48 compounds were identified from the EOs of C. Adulticidal bioassays of EO-permethrin mixtures for synergistic activity were also performed on these Ae. verum barks were evaluated for chemical compositions and adulticidal activity against Muang Chiang Mai-susceptible (MCM-S) and Pang Mai Dang-resistant (PMD-R) strains of Ae. aegypti, both pyrethroid-resistant and -susceptible strains. With the aim of reducing usage of conventional insecticides and improving the management of resistant mosquito populations, this study was designed to determine the potential synergism in the adulticidal efficacy of EOs on permethrin toxicity against Ae. In a previous screening program for mosquitocides from local edible plants in Thailand, essential oils (EOs) of Cyperus rotundus, Alpinia galanga and Cinnamomum verum, were found to possess promising adulticidal activity against Aedes aegypti.
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